TCF4 (dn) Adenovirus
Category: Adenovirus > Over-Expression
Cat. No: 1281
Availability:
Immediate
Name:
Ad-TCF4 (dn)
T cell factor-4 (Tcf-4) plays an important role in development and carcinogenesis. It directly binds to cytosolic β-catenin and facilitate its translocation to the nucleus. In the nucleus, these complexes induce expression various target genes.
The adenovirus expresses a dominant negative TCF4.
Reference: He TC., et al., Science. 1998 Sep 4;281(5382):1509-12.
$475.00
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Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- Volume
- 200ul
- Titer
- 1x10^10 PFU/ml
Gene Details
- Species
- Human
Product Citations
This product is referenced in the following publications:
- Amy Reynolds, etc (2013). Canonical Wnt signals combined with suppressed TGFß/BMP pathways promote renewal of the native human colonic epithelium. GUT.
- Taurin S, etc (2008). Phosphorylation Of Beta-Catenin By PKA Promotes ATP-Induced Proliferation Of Vascular Smooth Muscle Cells. Am J Physiol Cell Physiol.
- JS Rockel, etc (2016). Hedgehog inhibits ß-catenin activity in synovial joint development and osteoarthritis. JCI.
- Guo W, etc (2008). The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/ß-Catenin Signaling Pathways. J Biol Chem.
Control Products
| Product | Cat No. |
|---|---|
| Ad-CMV-Luc | 1000 |
| Ad-GFP | 1060 |
| Ad-CMV-b-Gal | 1080 |
| Ad-Null | 1240 |
| Ad-CMV-Null | 1300 |
| Ad-RFP | 1660 |
| Ad-CFP | 1766 |
| Ad-mCherry | 1767 |
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