TCF-4/TCF7L2 Adenovirus
Category: Adenovirus > Over-Expression
Cat. No: 1280
Availability:
Immediate
Name:
Ad-TCF4
T cell factor-4 (Tcf-4, also known as TCF7L2) plays an important role in development and carcinogenesis. It directly binds to cytosolic β-catenin and facilitate its translocation to the nucleus. In the nucleus, these complexes induce expression various target genes.
This adenovirus contain full length human TCF4.
Reference: Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma. Science (275):1784-1787. 1997
$475.00
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Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- Volume
- 200ul
- Titer
- 1x10^10 PFU/ml
Gene Details
- Species
- Human
- Gene Symbol
- TCF7L2
- Gene Synonyms
- TCF-4, TCF4, TCF7L2
Product Citations
This product is referenced in the following publications:
- Sylvia F. Boj, etc (2012). Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand. Cell.
- L Norton, etc (2014). The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Research.
- B Ye, etc (2019). Opposing roles of TCF7/LEF1 and TCF7L2 in cyclin D2 and Bmp4 expression and cardiomyocyte cell cycle control during late heart development. Laboratory Investigation.
- Guo W, etc (2008). The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/ß-Catenin Signaling Pathways. J Biol Chem.
Control Products
| Product | Cat No. |
|---|---|
| Ad-CMV-Luc | 1000 |
| Ad-GFP | 1060 |
| Ad-CMV-b-Gal | 1080 |
| Ad-Null | 1240 |
| Ad-CMV-Null | 1300 |
| Ad-RFP | 1660 |
| Ad-CFP | 1766 |
| Ad-mCherry | 1767 |
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