iKBa (S32A/S36A) Adenovirus
Category: Adenovirus > Over-Expression
Cat. No: 1028
Availability:
Immediate
Name:
Ad-CMV-iKB(DN)
This recombinant adenovirus contains the dominant-negative mutant of I kappa B alpha (IkBa-S32A/S36A), which has serine-to-alanine substitutions at amino acids 32 and 36, respectively, and is resistant to phosphorylation-induced degradation of I kappa B alpha.
References:Kumar, A., Eby, M. T., Sinha, S., Jasmin, A., and Chaudhary, P. M. (2000) J. Biol. Chem. 276, 2668-2677
$475.00
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Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- Volume
- 200ul
- Titer
- 1x10^10 PFU/ml
Gene Details
- Species
- Human
- Gene ID
- 4792
- RefSeq#
- NM_020529
Product Citations
This product is referenced in the following publications:
- Yacoub, A., etc. (2007). Human Chorionic Gonadotropin (Hcg) Modulates Prostate Cancer Cell Survival After Irradiation Or Hmg Coa Reductase Inhibitor Treatment. Molecular Pharmacology Fast Forward.
- Kao, DD. etc (2013). Tumor necrosis factor-a-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF¿B and MAPK regulates endothelial cell survival. Molecular and Cellular Biochemistry.
- Li, H., etc. (2007). Overexpression Of Myofibrillogenesis Regulator-1 Aggravates Cardiac Hypertrophy Induced By Angiotensin Ii In Mice. Hypertension.
- Yarilina, A., etc. (2008). Tnf Activates An Irf1-Dependent Autocrine Loop Leading To Sustained Expression Of Chemokines And Stat1-Dependent Type I Interferon¿Response Genes. Nature Immunology.
- Zhang, G., etc. (2008). Vorinostat And Sorafenib Synergistically Kill Tumor Cells Via Flip Suppression And Cd95 Activation. Clinical Cancer Research.
- Park MA, etc (2008). Vorinostat And Sorafenib Increase Er Stress, Autophagy And Apoptosis Via Ceramide-Dependent Cd95 And Perk Activation. Cancer Biol Ther.
- Reyna SM, etc (2008). Elevated Toll-Like Receptor 4 Expression And Signaling In Muscle From Insulin-Resistant Subjects. Diabetes.
- Matthias Zielonka, etc (2014). The I¿B Kinase Complex Is Required for Plexin-B-Mediated Activation of RhoA. PLOS One.
- Silva G, etc (2009). Oxidized Hemoglobin Is An Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells. J. Biol. Chem.
- Madalena Barroso, etc (2016). S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.
- NT Vu, etc (2016). Caspase-9b interacts directly with cIAP1 to drive agonist-independent activation of NF-¿B and lung tumorigenesis. Cancer Research.
- Li Z, etc (2017). Protective effects of Nebivolol against interleukin-1ß (IL-1ß)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13). Cell Stress and Chaperones.
- I Goldstein, etc (2017). Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading. Nature Communicationsvolume.
- K Saum, etc (2018). Uremic Advanced Glycation End Products and Protein-Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel-Like Factor 2. J Am Heart Assoc..
- L Décarie-Spain, etc (2018). Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Molecular Metabolism.
- SD Funk, etc (2018). EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity. Cellular Signalling.
- Seongmi Park (2009). The Receptor Interacting Protein 1 Inhibits p53 Induction through NF-¿B Activation and Confers a Worse Prognosis in Glioblastoma. Cancer Research.
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|---|---|
| Ad-CMV-Luc | 1000 |
| Ad-GFP | 1060 |
| Ad-CMV-b-Gal | 1080 |
| Ad-Null | 1240 |
| Ad-CMV-Null | 1300 |
| Ad-RFP | 1660 |
| Ad-CFP | 1766 |
| Ad-mCherry | 1767 |
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