Akt1 (dn) Adenovirus
Category: Adenovirus > Over-Expression
Cat. No: 1021
Availability:
Immediate
Name:
Ad-CMV-Akt1 (dn)
An HA tag was fused in frame to the N termini of the coding sequence of mouse Akt1(T308A, S473A) mutant, which is also known as Akt1(AA).
Akt1/PKB is activated in response to many extracellular signals and play key roles in regulating diverse cellular processes, including cell proliferation, differentiation, apoptosis, angiogenesis and glycogen synthesis etc. Akt1 is activated by the phosphorylation of the T loop of their kinase domain by PDK1 and by phosphorylation of a residue located C-terminal to the kinase domain in the hydrophobic motif.
The Akt family of kinases includes Akt1, Akt2 and Akt3.
$475.00
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Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- CMV (ubiquitous)
- Reporter
- HA
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- Volume
- 200ul
- Titer
- 1x10^10 PFU/ml
Gene Details
- Species
- Mouse
Product Citations
This product is referenced in the following publications:
- Li, T. etc (2011). Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem.
- Siong-Seng L., etc. (2008). HMGA1 Is A Molecular Determinant Of Chemoresistance To Gemcitabine In Pancreatic Adenocarcinoma. Clinical Cancer Research.
- Yacoub, A., etc. (2007). Human Chorionic Gonadotropin (Hcg) Modulates Prostate Cancer Cell Survival After Irradiation Or Hmg Coa Reductase Inhibitor Treatment. Molecular Pharmacology Fast Forward.
- Daniel R Premkumar, etc (2012). ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. JPET.
- Yacoub, A. etc (2008). Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Molecular Cancer Therapeutics.
- Yi-Ting Yeh, etc (2012). Convergence of physical and chemical signaling in the modulation of vascular smooth muscle cell cycle and proliferation by fibrillar collagen-regulated P66Shc. Biomaterials.
- Mitchell, C., etc. (2007). Low-Dose Bbr3610 Toxicity In Colon Cancer Cells Is P53-Independent And Enhanced By Inhibition Of Epidermal Growth Factor Receptor (Erbb1)-Phosphatidyl Inositol 3 Kinase Signaling. Mol Pharmacol.
- Park, M., etc. (2008). Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors And 17-Allylamino-17-Demethoxygeldanamycin Synergize To Kill Human Gastrointestinal Tumor Cells In Vitro Via Suppression Of C-Flip-S Levels And Activation Of Cd95. Molecular Cancer Therapeutics.
- Richard Seonghun Nho, etc (2013). FoxO3a (Forkhead Box O3a) Deficiency Protects Idiopathic Pulmonary Fibrosis (IPF) Fibroblasts from Type I Polymerized Collagen Matrix-Induced Apoptosis via Caveolin-1 (cav-1) and Fas. PLoS ONE.
- Yacoub, A. (2006). Osu-03012 Promotes Caspase-Independent But Perk-, Cathepsin B-, Bid-, And Aif-Dependent Killing Of Transformed Cells. Pharmacol.
- Park, M., etc. (2008). Osu-03012 Stimulates Pkr-Like Endoplasmic Reticulum-Dependent Increases In 70-Kda Heat Shock Protein Expression, Attenuating Its Lethal Actions In Transformed Cells. Mol Pharmacol.
- Sud N., etc. (2008). Protein Kinase C{Delta} Regulates Endothelial Nitric Oxide Synthase Expression Via Akt Activation And Nitric Oxide Generation. Am J Physiol Lung Cell Mol Physiol.
- Yacoub, A., etc. (2008). Regulation Of Gst-Mda-7 Toxicity In Human Glioblastoma Cells By Erbb1, Erk1/2, Pi3k, And Jnk1-3 Pathway Signaling. Molecular Cancer Therapeutics.
- Burger, D., etc (2006). Role Of Cytochrome C In Apoptosis: Increased Sensitivity To Tumor Necrosis Factor Alpha Is Associated With Respiratory Defects But Not With Lack Of Cytochrome C Release. Cardiovascular Research.
- Dedkova, N., etc. (2007). Signalling Mechanisms In Contraction-Mediated Stimulation Of Intracellular No Production In Cat Ventricular Myocytes. The Journal of Physiology.
- Zhang, G., etc. (2008). Vorinostat And Sorafenib Synergistically Kill Tumor Cells Via Flip Suppression And Cd95 Activation. Clinical Cancer Research.
- Park MA, etc (2008). Vorinostat And Sorafenib Increase Er Stress, Autophagy And Apoptosis Via Ceramide-Dependent Cd95 And Perk Activation. Cancer Biol Ther.
- Nho, RS. etc (2014). IPF Fibroblasts Are Desensitized to Type I Collagen Matrix-Induced Cell Death by Suppressing Low Autophagy via Aberrant Akt/mTOR Kinases. PLOS One.
- Burger DE, etc (2009). Erythropoietin Protects The Heart From Ventricular Arrhythmia During Ischemia And Reperfusion Via Neuronal Nitric-Oxide Synthase. J Pharmacol Exp Ther.
- Dodge J. etc (2008). Delivery Of Aav-IGF-1 To The CNS Extends Survival In ALS Mice Through Modification Of Aberrant Glial Cell Activity. Molecular Therapy.
- Park MA, etc (2009). Mek1/2 Inhibitors And 17AAG Synergize To Kill Human Gi Tumor Cells In Vitro Via Suppression Of C-Flip-S Levels And Activation Of Cd95. Mol Cancer Ther.
- Walker T, etc (2009). Sorafenib And Vorinostat Kill Colon Cancer Cells By Cd95-Dependent And -Independent Mechanisms. Mol Pharmacol.
- Anita K Sharma, etc (2014). Phosphorylation of AktSer473/Ask1Ser83 in Trolox-induced suppression of doxorubicin-induced changes in rat cardiomyocytes. Curr Res Cardiology.
- Martin, AP. etc (2009). Bcl-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor And Sorafenib Lethality Via Autophagy And Overcome Blockade Of The Extrinsic Pathway To Facilitate Killing. Mol Pharmacol.
- Burger, D. etc (2006). Erythropoietin Protects Cardiomyocytes From Apoptosis Via Up-Regulation Of Endothelial Nitric Oxide Synthase. Cardiovascular Research.
- Mitchell, C. etc (2007). Extrinsic Pathway- And Cathepsin-Dependent Induction Of Mitochondrial Dysfunction Are Essential For Synergistic Flavopiridol And Vorinostat Lethality In Breast Cancer Cells. Molecular Cancer Therapeutics.
- Alejandro P. Comellas (2010). Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt. Journal of Cell Science.
- Richard Seonghun Nho and Judy Kahm (2010). ß1-Integrin-Collagen Interaction Suppresses FoxO3a by the Coordination of Akt and PP2A. The Journal of Biological Chemistry.
- Adly Yacoub (2009). PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Research.
- Hossein A Hamed (2010). Inhibition of Multiple Protective Signaling Pathways and Ad. 5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma. Molecular Therapy.
- Adly Yacoub (2009). Cisplatin Enhances Protein Kinase R-Like Endoplasmic Reticulum Kinase- and CD95-Dependent Melanoma Differentiation-Associated Gene-7/Interleukin-24¿Induced Killing in Ovarian Carcinoma Cells. Molecular Pharmacology.
- Tan WQ. etc (2008). Foxo3a Inhibits Cardiomyocyte Hypertrophy Through Transactivating Catalase. J. Biol. Chem.
- Jintaek Im, etc (2016). Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3. Journal of Pathology.
- Wang Y, etc (2011). The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. Cancer Research.
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