Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice

Choi WS, etc
Osteoarthritis and Cartilage, 2016

Lipocalin-2 (LCN2) is a recently characterized adipokine that is upregulated in chondrocytes treated with pro-inflammatory mediators and in the synovial fluid of osteoarthritis (OA) patients. Here, we explored the in vivo functions of LCN2 in OA cartilage destruction in mice.

Our observations collectively suggest that upregulation of LCN2 in OA cartilage is not sufficient or necessary for OA cartilage destruction in mice.

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Journal
Osteoarthritis and Cartilage
Year
2016
Page
doi: 10.1016/j.joca.2016.07.009
Institute
Gwangju Institute of Science and Technology

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