human EIF2AK3 shRNA silencing AAV

Cat. No: shAAV-207708

Availability: 4-5 weeks

Name: AAV-h-EIF2AK3-shRNA

This is an AAV expressing shRNA for silencing of Human EIF2AK3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: EIF2AK3
Gene Name: eukaryotic translation initiation factor 2 alpha kinase 3
Gene ID: 9451
Gene Synonyms: PEK; PERK; WRS
ORF Size: 3348 bp
RefSeq#: NM_004836
Gene Description: EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
UniGene ID: Hs.591589
HGNC ID: HGNC:3255