human TPH2 Over-expression AAV

Cat. No: AAV-226257

Availability: 3-5 weeks

Name: AAV-h-TPH2

This is an AAV expressing Human TPH2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TPH2
Gene Name: tryptophan hydroxylase 2
Gene ID: 121278
Gene Synonyms: ADHD7; NTPH
ORF Size: 1473 bp
RefSeq#: BC114499
Gene Description: TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. TPH2 is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
UniGene ID: Hs.376337
HGNC ID: HGNC:20692