human PTGER4 shRNA silencing AAV

Cat. No: shAAV-220242

Availability: 4-5 weeks

Name: AAV-h-PTGER4-shRNA

This is an AAV expressing shRNA for silencing of Human PTGER4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTGER4
Gene Name: prostaglandin E receptor 4
Gene ID: 5734
Gene Synonyms: EP4; EP4R
ORF Size: 1467 bp
RefSeq#: NM_000958
Gene Description: PTGER4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
UniGene ID: Hs.199248
HGNC ID: HGNC:9596