human EDN3 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-207568
Availability:
3-5 weeks
Name:
AAV-h-EDN3
This is an AAV expressing Human EDN3.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- EDN3
- Gene Name
- endothelin 3
- Gene ID
- 1908
- Gene Synonyms
- ET3; HSCR4; MGC15067; MGC61498; WS4B;
- ORF Size
- 717 bp
- RefSeq#
- BC008876
- Gene Description
- EDN3 is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
- UniGene ID
- Hs.1408
- HGNC ID
- HGNC:3178
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