mouse KLHL20 shRNA silencing AAV

Cat. No: shAAV-262906

Availability: 6-8 weeks

Name: AAV-m-KLHL20-shRNA

This is an AAV expressing shRNA for silencing of Mouse Klhl20.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Klhl20
Gene Name: kelch-like 20
Gene ID: 226541
Gene Synonyms: AI504637; D930050H05Rik; Kleip; mKIAA4210
ORF Size: 1815 bp
RefSeq#: NM_001039482
Gene Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.
UniGene ID: Mm.255165