rat GRINL1A shRNA silencing AAV

Cat. No: shAAV-291981

Availability: 4-5 weeks

Name: AAV-r-GRINL1A-shRNA

This is an AAV expressing shRNA for silencing of Rat Polr2m.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Polr2m
Gene Name: RNA polymerase II subunit M
Gene ID: 192147
Gene Synonyms: Glurr; Grinl1a
ORF Size: 1095 bp
RefSeq#: NM_183402
Gene Description: Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.