rat SREBF2 shRNA silencing AAV

Cat. No: shAAV-294206

Availability: 4-5 weeks

Name: AAV-r-SREBF2-shRNA

This is an AAV expressing shRNA for silencing of Rat Srebf2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Srebf2
Gene Name: sterol regulatory element binding transcription factor 2
Gene ID: 300095
Gene Synonyms: Srebf2_retired; SREBP-2; SREBP2
ORF Size: 3402 bp
RefSeq#: NM_001033694
Gene Description: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.