rat NR1H4 shRNA silencing AAV

Cat. No: shAAV-293596

Availability: 4-5 weeks

Name: AAV-r-NR1H4-shRNA

This is an AAV expressing shRNA for silencing of Rat Nr1h4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Nr1h4
Gene Name: nuclear receptor subfamily 1, group H, member 4
Gene ID: 60351
Gene Synonyms: Fxr
ORF Size: 1452 bp
RefSeq#: NM_021745
Gene Description: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.