mouse ENPP2 shRNA silencing AAV

Cat. No: shAAV-258386

Availability: Immediate

Name: AAV-m-ENPP2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Enpp2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Enpp2
Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene ID: 18606
Gene Synonyms: ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha; Pdnp2
ORF Size: 2589 bp
RefSeq#: NM_015744
Gene Description: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
UniGene ID: Mm.250256