human BOLL shRNA silencing AAV

Cat. No: shAAV-202233

Availability: 6-8 weeks

Name: AAV-h-BOLL-shRNA

This is an AAV expressing shRNA for silencing of Human BOLL.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BOLL
Gene Name: boule homolog, RNA binding protein
Gene ID: 66037
Gene Synonyms: BOULE
ORF Size: 852 bp
RefSeq#: NM_033030
Gene Description: BOLL belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UniGene ID: Hs.169797
HGNC ID: HGNC:14273