mouse MAML1 shRNA silencing AAV

Cat. No: shAAV-264140

Availability: 4-5 weeks

Name: AAV-m-MAML1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Maml1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Maml1
Gene Name: mastermind like 1 (Drosophila)
Gene ID: 103806
Gene Synonyms: AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200
ORF Size: 2364 bp
RefSeq#: NM_175334
Gene Description: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
UniGene ID: Mm.51116