human PLCD1 shRNA silencing AAV

Cat. No: shAAV-219121

Availability: 4-5 weeks

Name: AAV-h-PLCD1-shRNA

This is an AAV expressing shRNA for silencing of Human PLCD1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PLCD1
Gene Name: phospholipase C delta 1
Gene ID: 5333
Gene Synonyms: NDNC3; PLC-III
ORF Size: 2271 bp
RefSeq#: NM_006225
Gene Description: PLCD1 encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.80776
HGNC ID: HGNC:9060