human DNM1 shRNA silencing AAV

Cat. No: shAAV-207200

Availability: 4-5 weeks

Name: AAV-h-DNM1-shRNA

This is an AAV expressing shRNA for silencing of Human DNM1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DNM1
Gene Name: dynamin 1
Gene ID: 1759
Gene Synonyms: DNM; EIEE31
ORF Size: 2556 bp
RefSeq#: NM_004408
Gene Description: DNM1 encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
UniGene ID: Hs.522413
HGNC ID: HGNC:2972