human F9 shRNA silencing AAV

Cat. No: shAAV-208237

Availability: 6-8 weeks

Name: AAV-h-F9-shRNA

This is an AAV expressing shRNA for silencing of Human F9.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: F9
Gene Name: coagulation factor IX
Gene ID: 2158
Gene Synonyms: F9 p22; FIX; HEMB; P19; PTC; THPH8
ORF Size: 1386 bp
RefSeq#: NM_000133
Gene Description: F9 encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
UniGene ID: Hs.522798
HGNC ID: HGNC:3551