human NR1H2 shRNA silencing AAV

Cat. No: shAAV-217031

Availability: 4-5 weeks

Name: AAV-h-NR1H2-shRNA

This is an AAV expressing shRNA for silencing of Human NR1H2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NR1H2
Gene Name: nuclear receptor subfamily 1 group H member 2
Gene ID: 7376
Gene Synonyms: LXR-b; LXRB; NER; NER-I; RIP15; UNR
ORF Size: 1386 bp
RefSeq#: NM_007121
Gene Description: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 (PubMed 19436111)).(supplied by OMIM, Jan 2010)
UniGene ID: Hs.432976
HGNC ID: HGNC:7965