human DOCK3 shRNA silencing AAV

Cat. No: shAAV-207228

Availability: 6-8 weeks

Name: AAV-h-DOCK3-shRNA

This is an AAV expressing shRNA for silencing of Human DOCK3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DOCK3
Gene Name: dedicator of cytokinesis 3
Gene ID: 1795
Gene Synonyms: MOCA; PBP
ORF Size: 6090 bp
RefSeq#: NM_004947
Gene Description: DOCK3 is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins (Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins) via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.
UniGene ID: Hs.476284
HGNC ID: HGNC:2989