human FGF23 shRNA silencing AAV

Cat. No: shAAV-208967

Availability: 6-8 weeks

Name: AAV-h-FGF23-shRNA

This is an AAV expressing shRNA for silencing of Human FGF23.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: FGF23
Gene Name: fibroblast growth factor 23
Gene ID: 8074
Gene Synonyms: ADHR; FGFN; HPDR2; HYPF; PHPTC
ORF Size: 756 bp
RefSeq#: NM_020638
Gene Description: FGF23 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
UniGene ID: Hs.287370
HGNC ID: HGNC:3680