mouse TRPM8 shRNA silencing AAV

Cat. No: shAAV-275100

Availability: 6-8 weeks

Name: AAV-m-TRPM8-shRNA

This is an AAV expressing shRNA for silencing of Mouse Trpm8.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Trpm8
Gene Name: transient receptor potential cation channel, subfamily M, member 8
Gene ID: 171382
Gene Synonyms: CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPP8
ORF Size: 3315 bp
RefSeq#: NM_134252
Gene Description: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
UniGene ID: Mm.218753