mouse SORBS2 shRNA silencing AAV

Cat. No: shAAV-272852

Availability: 6-8 weeks

Name: AAV-m-SORBS2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Sorbs2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Sorbs2
Gene Name: sorbin and SH3 domain containing 2
Gene ID: 234214
Gene Synonyms: 2010203O03Rik; 9430041O17Rik; A530071H08; Argbp2; mKIAA0777; nArgBP2
ORF Size: 3819 bp
RefSeq#: NM_172752
Gene Description: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
UniGene ID: Mm.447653