human STEAP2 shRNA silencing AAV

Cat. No: shAAV-224556

Availability: 4-5 weeks

Name: AAV-h-STEAP2-shRNA

This is an AAV expressing shRNA for silencing of Human STEAP2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: STEAP2
Gene Name: STEAP2 metalloreductase
Gene ID: 261729
Gene Synonyms: IPCA1; PCANAP1; PUMPCn; STAMP1; STMP
ORF Size: 1473 bp
RefSeq#: NM_152999
Gene Description: STEAP2 is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniGene ID: Hs.489051
HGNC ID: HGNC:17885