mouse NOP10 shRNA silencing AAV

Cat. No: shAAV-265929

Availability: 4-5 weeks

Name: AAV-m-NOP10-shRNA

This is an AAV expressing shRNA for silencing of Mouse Nop10.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Nop10
Gene Name: NOP10 ribonucleoprotein
Gene ID: 66181
Gene Synonyms: 1110036B12Rik; Nola3; NOP10P
ORF Size: 195 bp
RefSeq#: NM_025403
Gene Description: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
UniGene ID: Mm.272346