human OPA1 shRNA silencing AAV

Cat. No: shAAV-217420

Availability: 4-5 weeks

Name: AAV-h-OPA1-shRNA

This is an AAV expressing shRNA for silencing of Human OPA1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: OPA1
Gene Name: OPA1, mitochondrial dynamin like GTPase
Gene ID: 4976
Gene Synonyms: BERHS; largeG; MGM1; MTDPS14; NPG; NTG
ORF Size: 2883 bp
RefSeq#: NM_130832
Gene Description: OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.594504
HGNC ID: HGNC:8140