human CRTC2 shRNA silencing AAV

Cat. No: shAAV-206039

Availability: 4-5 weeks

Name: AAV-h-CRTC2-shRNA

This is an AAV expressing shRNA for silencing of Human CRTC2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CRTC2
Gene Name: CREB regulated transcription coactivator 2
Gene ID: 200186
Gene Synonyms: TORC-2; TORC2
ORF Size: 2082 bp
RefSeq#: NM_181715
Gene Description: CRTC2 encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
UniGene ID: Hs.406392
HGNC ID: HGNC:27301