human RANGAP1 shRNA silencing AAV

Cat. No: shAAV-220709

Availability: 4-5 weeks

Name: AAV-h-RANGAP1-shRNA

This is an AAV expressing shRNA for silencing of Human RANGAP1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RANGAP1
Gene Name: Ran GTPase activating protein 1
Gene ID: 5905
Gene Synonyms: Fug1; RANGAP; SD
ORF Size: 1764 bp
RefSeq#: NM_002883
Gene Description: RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
UniGene ID: Hs.183800
HGNC ID: HGNC:9854