human PDZK1 shRNA silencing AAV

Cat. No: shAAV-218579

Availability: 6-8 weeks

Name: AAV-h-PDZK1-shRNA

This is an AAV expressing shRNA for silencing of Human PDZK1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDZK1
Gene Name: PDZ domain containing 1
Gene ID: 5174
Gene Synonyms: CAP70; CLAMP; NHERF-3; NHERF3; PDZD1
ORF Size: 1560 bp
RefSeq#: NM_002614
Gene Description: PDZK1 encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.444751
HGNC ID: HGNC:8821