human UHRF2 shRNA silencing AAV

Cat. No: shAAV-227166

Availability: 6-8 weeks

Name: AAV-h-UHRF2-shRNA

This is an AAV expressing shRNA for silencing of Human UHRF2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UHRF2
Gene Name: ubiquitin like with PHD and ring finger domains 2
Gene ID: 115426
Gene Synonyms: NIRF; RNF107; TDRD23; URF2
ORF Size: 1512 bp
RefSeq#: NM_152896
Gene Description: UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
UniGene ID: Hs.493401
HGNC ID: HGNC:12557