human PMS2 shRNA silencing AAV

Cat. No: shAAV-219280

Availability: 6-8 weeks

Name: AAV-h-PMS2-shRNA

This is an AAV expressing shRNA for silencing of Human PMS2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PMS2
Gene Name: PMS1 homolog 2, mismatch repair system component
Gene ID: 5395
Gene Synonyms: HNPCC4; MLH4; PMS2CL; PMSL2
ORF Size: 2589 bp
RefSeq#: NM_000535
Gene Description: PMS2 is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
UniGene ID: Hs.632637
HGNC ID: HGNC:9122