human ESR2 shRNA silencing AAV

Cat. No: shAAV-208116

Availability: 6-8 weeks

Name: AAV-h-ESR2-shRNA

This is an AAV expressing shRNA for silencing of Human ESR2.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ESR2
Gene Name: estrogen receptor 2
Gene ID: 2100
Gene Synonyms: ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2
ORF Size: 972 bp
RefSeq#: NM_001437
Gene Description: ESR2 encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
UniGene ID: Hs.660607
HGNC ID: HGNC:3468