human A2BP1 shRNA silencing AAV

Cat. No: shAAV-200005

Availability: 6-8 weeks

Name: AAV-h-A2BP1-shRNA

This is an AAV expressing shRNA for silencing of Human RBFOX1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RBFOX1
Gene Name: RNA binding protein, fox-1 homolog 1
Gene ID: 54715
Gene Synonyms: 2BP1; A2BP1; FOX-1; FOX1; HRNBP1
ORF Size: 1188 bp
RefSeq#: NM_145891
Gene Description: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.459842
HGNC ID: HGNC:18222