human MAP3K8 shRNA silencing AAV

Cat. No: shAAV-214942

Availability: 4-5 weeks

Name: AAV-h-MAP3K8-shRNA

This is an AAV expressing shRNA for silencing of Human MAP3K8.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MAP3K8
Gene Name: mitogen-activated protein kinase kinase kinase 8
Gene ID: 1326
Gene Synonyms: AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
ORF Size: 1404 bp
RefSeq#: NM_005204
Gene Description: MAP3K8 is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. MAP3K8 may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
UniGene ID: Hs.432453
HGNC ID: HGNC:6860