mouse SNF8 shRNA silencing AAV

Cat. No: shAAV-272723

Availability: 4-5 weeks

Name: AAV-m-SNF8-shRNA

This is an AAV expressing shRNA for silencing of Mouse Snf8.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Snf8
Gene Name: SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
Gene ID: 27681
Gene Synonyms: D11Moh34
ORF Size: 777 bp
RefSeq#: NM_033568
Gene Description: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
UniGene ID: Mm.372235