human CBFA2T3 shRNA silencing AAV

Cat. No: shAAV-204159

Availability: 4-5 weeks

Name: AAV-h-CBFA2T3-shRNA

This is an AAV expressing shRNA for silencing of Human CBFA2T3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CBFA2T3
Gene Name: CBFA2/RUNX1 translocation partner 3
Gene ID: 863
Gene Synonyms: ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4
ORF Size: 1962 bp
RefSeq#: NM_005187
Gene Description: CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. CBFA2T3 is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
UniGene ID: Hs.513811
HGNC ID: HGNC:1537