mouse FAM175A shRNA silencing AAV

Cat. No: shAAV-259024

Availability: 4-5 weeks

Name: AAV-m-FAM175A-shRNA

This is an AAV expressing shRNA for silencing of Mouse Fam175a.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fam175a
Gene Name: family with sequence similarity 175, member A
Gene ID: 70681
Gene Synonyms: 3830405G04Rik; 5630400M01Rik; AI506069; AL024423; AV118690; Ccdc98
ORF Size: 897 bp
RefSeq#: NM_172405
Gene Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
UniGene ID: Mm.221269