human GCLC shRNA silencing AAV

Cat. No: shAAV-209745

Availability: 4-5 weeks

Name: AAV-h-GCLC-shRNA

This is an AAV expressing shRNA for silencing of Human GCLC.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GCLC
Gene Name: glutamate-cysteine ligase catalytic subunit
Gene ID: 2729
Gene Synonyms: GCL; GCS; GLCL; GLCLC
ORF Size: 1914 bp
RefSeq#: NM_001498
Gene Description: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
UniGene ID: Hs.654465
HGNC ID: HGNC:4311