human PON3 shRNA silencing AAV

Cat. No: shAAV-219445

Availability: 4-5 weeks

Name: AAV-h-PON3-shRNA

This is an AAV expressing shRNA for silencing of Human PON3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PON3
Gene Name: paraoxonase 3
Gene ID: 5446
ORF Size: 1065 bp
RefSeq#: NM_000940
Gene Description: PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
UniGene ID: Hs.440967
HGNC ID: HGNC:9206