human ACTL6A shRNA silencing AAV

Cat. No: shAAV-200294

Availability: 4-5 weeks

Name: AAV-h-ACTL6A-shRNA

This is an AAV expressing shRNA for silencing of Human ACTL6A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACTL6A
Gene Name: actin like 6A
Gene ID: 86
Gene Synonyms: ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K
ORF Size: 1164 bp
RefSeq#: NM_177989
Gene Description: ACTL6A encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL6A encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
UniGene ID: Hs.435326
HGNC ID: HGNC:24124