human CHKB shRNA silencing AAV

Cat. No: shAAV-205150

Availability: 4-5 weeks

Name: AAV-h-CHKB-shRNA

This is an AAV expressing shRNA for silencing of Human CHKB.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CHKB
Gene Name: choline kinase beta
Gene ID: 1120
Gene Synonyms: CHETK; CHKL; CK; CKB; CKEKB; EK; EKB; MDCMC
ORF Size: 1188 bp
RefSeq#: NM_005198
Gene Description: Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.
UniGene ID: Hs.654827
HGNC ID: HGNC:1938