human UNC13D shRNA silencing AAV

Cat. No: shAAV-227185

Availability: 4-5 weeks

Name: AAV-h-UNC13D-shRNA

This is an AAV expressing shRNA for silencing of Human UNC13D.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UNC13D
Gene Name: unc-13 homolog D
Gene ID: 201294
Gene Synonyms: FHL3; HLH3; HPLH3; Munc13-4
ORF Size: 3273 bp
RefSeq#: NM_199242
Gene Description: UNC13D encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
UniGene ID: Hs.41045
HGNC ID: HGNC:23147