human CBX3 shRNA silencing AAV

Cat. No: shAAV-204198

Availability: 4-5 weeks

Name: AAV-h-CBX3-shRNA

This is an AAV expressing shRNA for silencing of Human CBX3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CBX3
Gene Name: chromobox 3
Gene ID: 11335
Gene Synonyms: HECH; HP1-GAMMA; HP1Hs-gamma
ORF Size: 552 bp
RefSeq#: NM_007276
Gene Description: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
UniGene ID: Hs.381189
HGNC ID: HGNC:1553