human CSF1R shRNA silencing AAV

Cat. No: shAAV-211307

Availability: 6-8 weeks

Name: AAV-h-CSF1R-shRNA

This is an AAV expressing shRNA for silencing of Human CSF1R.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CSF1R
Gene Name: colony stimulating factor 1 receptor
Gene ID: 1436
Gene Synonyms: C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R
ORF Size: 2919 bp
RefSeq#: NM_005211
Gene Description: CSF1R is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
UniGene ID: Hs.586219
HGNC ID: HGNC:2433