human TPCN2 shRNA silencing AAV

Cat. No: shAAV-226249

Availability: 4-5 weeks

Name: AAV-h-TPCN2-shRNA

This is an AAV expressing shRNA for silencing of Human TPCN2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TPCN2
Gene Name: two pore segment channel 2
Gene ID: 219931
Gene Synonyms: SHEP10; TPC2
ORF Size: 2259 bp
RefSeq#: NM_139075
Gene Description: TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
UniGene ID: Hs.131851
HGNC ID: HGNC:20820