human TGFBR1 shRNA silencing AAV

Cat. No: shAAV-225390

Availability: 4-5 weeks

Name: AAV-h-TGFBR1-shRNA

This is an AAV expressing shRNA for silencing of Human TGFBR1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TGFBR1
Gene Name: transforming growth factor beta receptor 1
Gene ID: 7046
Gene Synonyms: AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TGFR-1
ORF Size: 1281 bp
RefSeq#: NM_004612
Gene Description: TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.494622
HGNC ID: HGNC:11772