human YWHAZ shRNA silencing AAV

Cat. No: shAAV-228009

Availability: 4-5 weeks

Name: AAV-h-YWHAZ-shRNA

This is an AAV expressing shRNA for silencing of Human YWHAZ.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: YWHAZ
Gene Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Gene ID: 7534
Gene Synonyms: 14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4; KCIP-1; YWHAD
ORF Size: 738 bp
RefSeq#: NM_003406
Gene Description: YWHAZ product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
UniGene ID: Hs.492407
HGNC ID: HGNC:12855