human BIN1 shRNA silencing AAV

Cat. No: shAAV-202141

Availability: 4-5 weeks

Name: AAV-h-BIN1-shRNA

This is an AAV expressing shRNA for silencing of Human BIN1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BIN1
Gene Name: bridging integrator 1
Gene ID: 274
Gene Synonyms: AMPH2; AMPHL; SH3P9
ORF Size: 1320 bp
RefSeq#: NM_004305
Gene Description: BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
UniGene ID: Hs.193163
HGNC ID: HGNC:1052