human NRAS shRNA silencing AAV

Cat. No: shAAV-217066

Availability: 4-5 weeks

Name: AAV-h-NRAS-shRNA

This is an AAV expressing shRNA for silencing of Human NRAS.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NRAS
Gene Name: neuroblastoma RAS viral oncogene homolog
Gene ID: 4893
Gene Synonyms: ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6
ORF Size: 570 bp
RefSeq#: NM_002524
Gene Description: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
UniGene ID: Hs.486502
HGNC ID: HGNC:7989